On Multan~Sukkur motorway I've seen atleast 2 pumps yesterday while on national highway plenty of other pumps.
I fill it in Sukkur from Shell and then next in Karachi.
@waqar747 bhai gave me very good recommendations on my first trip. So I'll just give you the mixed summary.
Hotels in Sukkur:
Chen Inn
Hotel One
Route:
Till Sukkur you'll have motorway.
Start of Sukkur you'll have national highway, stay on that till Hyderabad. Then Hyderabad-Karachi Motorway. (The only Motorway where I've seen Bikes, Rikshaws as well
)
Note: At QaziAhmed Google map will tell you to turn right (a kind of u-turn and then there's a single road till Khanote. Never ever trun there, it's a nightmare. Just stay on national highway.
This one:
NEVER, EVER turn there. Just go straight.
Food:
Homemade cooked or packed food. Personally I don't eat on the way, and for family I exit from the motorway and find the best one on google. On National highway only Taj hotels.
Do check weather conditions/reports/news before starting the journey.
Baqi best of luck, have a safe travels. Allah apka haami o nasir.